Sang Taek Jung Ph.D.

SANG TAEK JUNG

Department of Biomedical Sciences, Graduate School of Medicine, Korea University

73, Goryeodae-ro, Seongbuk-gu, Seoul, Korea, 02841

Office: +82-2-2286-1422

E-mail: sjung@korea.ac.kr 

CV File

EDUCATION 

     Ph.D. Chemical Engineering

     Thesis: Engineering of Aglycosylated Antibody Fc for Effector Functions

     M.S. Chemical Technology (now Chemical and Biological Engineering)

     Thesis: Production and Purification of Recombinant Human Erythropoietin in Escherichia coli and Chemical Modification with Monomethoxy Polyethylene Glycol

     B.S. Chemical Technology (now Chemical and Biological Engineering)

     Thesis: Wear Properties of Polymer (Ultra-High Molecular Weight Polyethylene) for Artificial Bone (Class Rank : 2nd in the Department)

PROFESSIONAL EXPERIENCE  

     Department of Biomedical Sciences, Graduate School of Medicine, Korea University

     Antibody Engineering, Protein Engineering, and Applied Immunology


     Department of Chemical Engineering, The University of Texas at Austin

     Antibody and Protein Engineering


     Department of Applied Chemistry, Kookmin University

     Antibody Engineering, Protein Engineering, and Applied Immunology


     Department of Chemical Engineering, The University of Texas at Austin 

     Advisor: Prof. George Georgiou

     Applied Immunology:

     - Antibody discovery via proteomic tools and bioinformatic analysis

     - Recruitment of endogenous antibodies for cancer immunotherapy

     - Engineering antibody for enhanced potency and stability


     Division of Chemistry and Chemical Engineering, California Institute of Technology

     Advisor: Prof. Frances H. Arnold, Nobel Prize Laureate in Chemistry (2018

     Evolutionary Design of Biological Systems:

     - Directed evolution of cytochrome P450 heme domain for ligand specific functional MRI contrast agents

     - Enzyme evolution for non-natural heme-incorporated proteins

     - Directed evolution of cytochrome P450 BM3 for chemicals and biofuels


     Department of Chemical Engineering, The University of Texas at Austin

     Advisor: Prof. George Georgiou

     Antibody Engineering:

    - Engineering antibodies for selective binding to activating low affinity Fc receptors and enhanced therapeutic effector functions

       functions.

    - Designing and screening of antibodies for improved HIV neutralization.


     Department of Chemical Engineering, The University of Texas at Austin

     Advisor: Prof. George Georgiou

     Antibody Engineering, High Throughput Screening, and Bacteria Physiology:

     - Engineering of aglycosylated antibody Fc for unique effector functions

     - Development of a high throughput antibody screening system for insoluble antigens

     - Development of covalently anchored full-length IgG display system

     - Bacterial production and characterization of human Fc receptors

    

     Samyang Genex Biotech Research Institute

     Development of Protein Therapeutics:

     - Development of fermentation and purification process for human G-CSF from E. coli

     - Genetic optimization for high-level expression of G-CSF in E. coli

     - Cloning, production, and characterization of lysyl oxidase family proteins for anticancer drugs


     Green Cross Corporation

     Development of Vaccines and Diagnostics:

Researcher in Rotavirus Vaccine Research Team

     - Scale-up to 75L scale and optimization of baculovirus-infected insect cell (Sf9) culture for the production of rotavirus-like particle (VLP) vaccine

     - Development of purification process for rotavirus-like particle vaccine

     - Development of rotavirus detection kit (Rotatek™)


     Seoul National University

     Advisor: Prof. Cha Yong Choi

     Protein Engineering:

     - Production and purification of human erythropoietin in E. coli

     - Chemical modification of human erythropoietin using polyethylene glycol for the enhancement of half-life and serum stability


     Seoul National University

     Advisor: Prof. Cha Yong Choi

     Genetic Engineering:

     - Cloning and expression of human erythropoietin in E. coli.